17-AAG (Tanespimycin)

Name: 17-AAG (Tanespimycin)
Brand: AOBIOUS
SKU: AOB5916
Price: 11 USD
Availability: InStock

Cat No: AOB5916

Condition

CAS: 75747-14-7

Chemical Name: Tanespimycin; 17-Allylaminogeldanamycin; NSC-330507; 17-Demethoxy-17-(2-propenylamino)geldanamycin

More details

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$9.35	Total: $46.75
1	10	$7.92	Total: $79.20
1	25	$6.71	Total: $167.75
1	50	$5.72	Total: $286.00
1	100	$4.95	Total: $495.00

Overview

Inhibitor of heat shock protein 90 (Hsp90) chaperone activity

Chemical Properties

Molecular Formula	C31H43N3O8
Molecular Weight	585.69
CAS Numbers	75747-14-7
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(4E,6E,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate.
InChl Key	AYUNIORJHRXIBJ-HTLBVUBBSA-N
InChl Code	InChI=1S/C31H43N3O8/c1-8-12-33-26-21-13-17(2)14-25(41-7)27(36)19(4)15-20(5)29(42-31(32)39)24(40-6)11-9-10-18(3)30(38)34-22(28(21)37)16-23(26)35/h8-11,15-17,19,24-25,27,29,33,36H,1,12-14H2,2-7H3,(H2,32,39)(H,34,38)/b11-9+,18-10+,20-15+/t17-,19+,24+,25+,27-,29+/m1/s1
SMILES Code	NC(O[C@@H](/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC1=C2NCC=C)[C@@H](OC)/C=C/C=C(C)/C(NC(C1=O)=CC2=O)=O)=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

17-AAG, 17 AAG, 17AAG, BAY 57-9352, BAY 579352, BAY579352, KOS-953, KOS-953, KOS-953, Tanespimycin

References

1) Chen SZ, Chen XM, Li YQ, Yang S, Mo XY, Zhang F, Mo KL, Ding Y. [Inhibitory effect of 17-AAG combined with paclitaxel on proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2015 Jun 20;35(6):844-7. Chinese. PubMed PMID: 26111682.

2) Yun IS, Lee MH, Rah DK, Lew DH, Park JC, Lee WJ. Heat Shock Protein 90 Inhibitor (17-AAG) Induces Apoptosis and Decreases Cell Migration/Motility of Keloid Fibroblasts. Plast Reconstr Surg. 2015 Jul;136(1):44e-53e. doi: 10.1097/PRS.0000000000001362. PubMed PMID: 26111331.