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> Pathway Inhibitors>Enzyme Inhibitors>SHMT-IN-2

Enzyme Inhibitors

SHIN2 View larger

SHMT-IN-2

AOB31454

CAS: 2102681-49-0

 

Chemical Name: Serine hydroxymethyltranferase inhibitor 2; 6-Amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $22.95 Total: $114.75
110 $19.44 Total: $194.40
125 $16.47 Total: $411.75
150 $14.04 Total: $702.00
1100 $12.15 Total: $1,215.00

Data sheet

Molecular FormulaC22H24F3N5O
Molecular Weight431.46
CAS Numbers2102681-49-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymSHMT-IN-2, Serine hydroxymethyltranferase inhibitor 2
IUPAC/Chemical Name6-Amino-4-isopropyl-3-methyl-4-(3-(pyrrolidin-1-yl)-5-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
InChl KeyNOKJZHRLDAOFCV-UHFFFAOYSA-N
InChl Code InChI=1S/C22H24F3N5O/c1-12(2)21(17(11-26)19(27)31-20-18(21)13(3)28-29-20)14-8-15(22(23,24)25)10-16(9-14)30-6-4-5-7-30/h8-10,12H,4-7,27H2,1-3H3,(H,28,29)
SMILES CodeN#CC(C1(C(C)C)C2=CC(C(F)(F)F)=CC(N3CCCC3)=C2)=C(N)OC4=C1C(C)=NN4
ReferencesGregory S et al., Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma, PNAS October 24, 2017 114 (43) 11404-11409; first published October 9, 2017 https://doi.org/10.1073/pnas.1706617114

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Novel serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.

SHMT-IN-2 is an analog of SHIN2 (AOB11286)

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