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GS-441524
AOB36496
CAS No: 1191237-69-0
FOR READY TO USE SOLUTION CLICK: AOB36496S
AOBIOUS launched this product in 2020
CITATIONS - Publications That Use AOBIOUS Product
This product is intended for scientific researcher only
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | 50 mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $13.50 | Total: $1,350.00 |
| 1 | 50 | $15.60 | Total: $780.00 |
| 1 | 25 | $18.30 | Total: $457.50 |
| 1 | 10 | $21.60 | Total: $216.00 |
| 1 | 5 | $25.50 | Total: $127.50 |
Data sheet
| Molecular Formula | C12H13N5O4 |
| Molecular Weight | 291.27 |
| CAS Numbers | 1191237-69-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | GS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite |
| IUPAC/Chemical Name | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile |
| InChl Key | BRDWIEOJOWJCLU-LTGWCKQJSA-N |
| InChl Code | InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1 |
| SMILES Code | N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O |
| References | 1) Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281. 2) Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233. |
More info
A novel precursor of potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. It only becomes effective pharmacologically when it was formed as its triphosphate analog in situ.
GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.
REFERENCE:
1) Murphy BG, etc. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 219:226-233 (2018). doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200
2) J Feline Med Surg. 2019 Apr; 21(4): 271–281.
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