Enzyme Inhibitors

GS-441524 View larger

GS-441524

AOB36496

CAS No: 1191237-69-0

FOR READY TO USE SOLUTION CLICK:  AOB36496S

More details

This product is intended for scientific researcher doing FIP studies and NOT be used by cat guardians to attempt to treat their cats.

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$3.00

$3.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $1.35 Total: $135.00
50 $1.56 Total: $78.00
25 $1.83 Total: $45.75
10 $2.16 Total: $21.60
5 $2.55 Total: $12.75

Data sheet

Molecular FormulaC12H13N5O4
Molecular Weight291.27
CAS Numbers1191237-69-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymGS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite
IUPAC/Chemical Name(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
InChl KeyBRDWIEOJOWJCLU-LTGWCKQJSA-N
InChl CodeInChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
SMILES CodeN#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O
References1) Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281.

2) Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233.

More info

A novel precursor of potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. It only becomes effective pharmacologically when it was formed as its triphosphate analog in situ.


GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.


REFERENCE:

1) Murphy BG, etc. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 219:226-233 (2018). doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200

2) J Feline Med Surg. 2019 Apr; 21(4): 271–281.

3) Dr. Perdersen Recent Update

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