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ONO-1301
AOB31733
CAS: 176391-41-6
Chemical Name: 2-[[6-Methyl-5-[2-[(E)-[phenyl(pyridin-3-yl)methylidene]amino]oxyethyl]-7,8-dihydronaphthalen-1-yl]oxy]acetic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $22.05 | Total: $2,205.00 |
| 1 | 50 | $25.48 | Total: $1,274.00 |
| 1 | 25 | $29.89 | Total: $747.25 |
| 1 | 10 | $35.28 | Total: $352.80 |
| 1 | 5 | $41.65 | Total: $208.25 |
Data sheet
| Molecular Formula | C27H26N2O4 |
| Molecular Weight | 442.51 |
| CAS Numbers | 176391-41-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Water |
| Purity | 98% by HPLC |
| Synonym | Ono1301; Ono-1301; Ono 1301 |
| IUPAC/Chemical Name | (Z)-2-((6-methyl-5-(2-(((phenyl(pyridin-3-yl)methylene)amino)oxy)ethyl)-7,8-dihydronaphthalen-1-yl)oxy)acetic acid |
| InChl Key | VSVQEQDGOFPGAT-OHYPFYFLSA-N |
| InChl Code | InChI=1S/C27H26N2O4/c1-19-12-13-24-23(10-5-11-25(24)32-18-26(30)31)22(19)14-16-33-29-27(20-7-3-2-4-8-20)21-9-6-15-28-17-21/h2-11,15,17H,12-14,16,18H2,1H3,(H,30,31)/b29-27- |
| SMILES Code | O=C(O)COC1=C2CCC(C)=C(CCO/N=C(C3=CC=CC=C3)C4=CC=CN=C4)C2=CC=C1 |
| References | 1) Kashiwagi H, Yuhki K, Kojima F, Kumei S, Takahata O, Sakai Y, Narumiya S, Ushikubi F. The novel prostaglandin I2 mimetic ONO-1301 escapes desensitization in an antiplatelet effect due to its inhibitory action on thromboxane A2 synthesis in mice. J Pharmacol Exp Ther. 2015 May;353(2):269-78. 2) Watatani H, Yamasaki H, Maeshima Y, Nasu T, Hinamoto N, Ujike H, Sugiyama H, Sakai Y, Tanabe K, Makino H. ONO-1301, a sustained-release prostacyclin analog, ameliorates the renal alterations in a mouse type 2 diabetes model possibly through its protective effects on mesangial cells. Acta Med Okayama. 2015;69(1):1-15. PubMed PMID: 25703166. |
| PubChem ID | 24753719 |
More info
Novel Long-Acting Prostacyclin Agonist, Promoting Synthesis of Hepatocyte Growth Factor and Increasing Cyclic AMP Concentration via IP-Receptor Signaling
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