Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
SHIN1
AOB36697
CAS: 2146095-85-2
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
1) J Clin Invest. 2021 Aug 2; 131(15): e138022.
2) Cell Metabolism, V31(5), P920-936.E7, MAY 05, 2020
3) Aus dem Institut für Medizinische Mikrobiologie und Krankenhaushygiene (2022)
349 Items
Analog of AOB31454
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $21.25 | Total: $106.25 |
| 1 | 10 | $18.00 | Total: $180.00 |
| 1 | 25 | $15.25 | Total: $381.25 |
| 1 | 50 | $13.00 | Total: $650.00 |
| 1 | 100 | $11.25 | Total: $1,125.00 |
Overview
Serine hydroxymethyltransferase (SHMT) inhibitor, potently inhibiting both human SHMT1/2.
Also check SHMT-IN-2 (AOB31454) and SHIN2 (AOB11286) two close analogs of SHIN1 that share the same pharmacological profile.
Chemical Properties
| Molecular Formula | C24H24N4O2 |
| Molecular Weight | 400.47 |
| CAS Numbers | 2146095-85-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile |
| InChl Key | VVVOFJZXKJKHTD-UHFFFAOYSA-N |
| SMILES Code | CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064
Customers who bought this product also bought:
-
$13.00
-
$48.75
-
$102.70
-
$13.00
-
$14.30
-
$13.00
