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PMPA
AOB37013
CAS: 173039-10-6
Chemical Name: 2-(Phosphonomethyl)pentane-1,5-dioic acid
999 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Highly potent and selective inhibitor of glutamate carboxypeptidase 2 (GCP II/N-acetylated a-linked dipeptidase/NAALADase)
Chemical Properties
| Molecular Formula | C6H11O7P |
| Molecular Weight | 226.12 |
| CAS Numbers | 173039-10-6 (free acid) |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-(phosphonomethyl)pentanedioic acid |
| InChl Key | ISEYJGQFXSTPMQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H11O7P/c7-5(8)2-1-4(6(9)10)3-14(11,12)13/h4H,1-3H2,(H,7,8)(H,9,10)(H2,11,12,13) |
| SMILES Code | O=C(O)C(CP(O)(O)=O)CCC(O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PMPA, NAALADase inhibitor; PMPA sodium
References
1) Majer P, et al. Discovery of Orally Available Prodrugs of the Glutamate Carboxypeptidase II (GCPII) Inhibitor 2-Phosphonomethylpentanedioic Acid (2-PMPA). J Med Chem. 2016 Mar 24;59(6):2810-9. doi: 10.1021/acs.jmedchem.6b00062. PubMed PMID: 26930119.
2) Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA). J Pharm Biomed Anal. 2014 Jan;88:162-9. doi: 10.1016/j.jpba.2013.08.028. PubMed PMID: 24055700; PubMed Central PMCID: PMC3891469.
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