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TAK-981
AOB14037
CAS: 1858276-04-6
Chemical Name: ((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
998 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $126.65 | Total: $633.25 |
| 1 | 10 | $107.28 | Total: $1,072.80 |
| 1 | 25 | $90.89 | Total: $2,272.25 |
| 1 | 50 | $77.48 | Total: $3,874.00 |
| 1 | 100 | $67.05 | Total: $6,705.00 |
Overview
First-in-Class Inhibitor of SUMO-Activating Enzyme (SAE) for the Treatment of Cancer
Chemical Properties
| Molecular Formula | C25H28ClN5O5S2 |
| Molecular Weight | 578.099 |
| CAS Numbers | 1858276-04-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | [(1R,2S,4R)-4-[(5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl)amino]-2-hydroxycyclopentyl]methyl sulfamate |
| InChl Key | LXRZVMYMQHNYJB-UNXOBOICSA-N |
| InChl Code | InChI=1S/C25H28ClN5O5S2/c1-13-18(23-19-7-16(26)3-2-14(19)4-5-29-23)9-22(37-13)24(33)20-10-28-12-30-25(20)31-17-6-15(21(32)8-17)11-36-38(27,34)35/h2-3,7,9-10,12,15,17,21,23,29,32H,4-6,8,11H2,1H3,(H2,27,34,35)(H,28,30,31)/t15-,17-,21+,23+/m1/s1 |
| SMILES Code | O=S(OC[C@@H]1[C@@H](O)C[C@H](NC2=NC=NC=C2C(C3=CC([C@@H]4NCCC5=C4C=C(Cl)C=C5)=C(C)S3)=O)C1)(N)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
TAK-981; TAK 981; TAK981;
References
1) ERIC S. LIGHTCAP et al., A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models, SCIENCE TRANSLATIONAL MEDICINE VOL. 13, NO. 611
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