GS-441524

Name: GS-441524
Brand: AOBIOUS
SKU: AOB36496
Price: 30 USD
Availability: InStock

Cat No: AOB36496

Condition

CAS No: 1191237-69-0

FOR READY TO USE SOLUTION CLICK: AOB36496S

AOBIOUS launched this product in 2020

CITATIONS - Publications That Use AOBIOUS Product

1) J Antimicrob Chemother. 2021 Apr 17 : dkab094.

More details

14859 Item Items

This product is intended for scientific researcher only

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	50 mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$25.50	Total: $127.50
1	10	$21.60	Total: $216.00
1	25	$18.30	Total: $457.50
1	50	$15.60	Total: $780.00
1	100	$13.50	Total: $1,350.00

Overview

A novel precursor of potent inhibitor of feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. It only becomes effective pharmacologically when it was formed as its triphosphate analog in situ.

GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.

REFERENCE:

1) Murphy BG, etc. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 219:226-233 (2018). doi: 10.1016/j.vetmic.2018.04.026. Epub 2018 Apr 22. PubMed PMID: 29778200

2) J Feline Med Surg. 2019 Apr; 21(4): 271–281.

3) Dr. Perdersen Recent Update

Chemical Properties

Molecular Formula	C12H13N5O4
Molecular Weight	291.27
CAS Numbers	1191237-69-0
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
InChl Key	BRDWIEOJOWJCLU-LTGWCKQJSA-N
InChl Code	InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1
SMILES Code	N#C[C@@]1(C2=CC=C3C(N)=NC=NN32)O[C@H](CO)[C@@H](O)[C@H]1O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

GS-441524; GS 441524; GS441524; Remdesivir-metabolite, GS-5734-metabolite; GS5734-metabolite; GS 5734-metabolite

References

1) Pedersen NC, Perron M, Bannasch M, Montgomery E, Murakami E, Liepnieks M, Liu H. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis. J Feline Med Surg. 2019 Apr;21(4):271-281.

2) Murphy BG, Perron M, Murakami E, Bauer K, Park Y, Eckstrand C, Liepnieks M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Vet Microbiol. 2018 Jun;219:226-233.