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View larger E6446 dihydrochloride
AT4068
CAS 1345675-25-3
Molarity Calculation Cart®
HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $41.85 | Total: $4,185.00 |
| 1 | 50 | $48.36 | Total: $2,418.00 |
| 1 | 25 | $56.73 | Total: $1,418.25 |
| 1 | 10 | $66.96 | Total: $669.60 |
| 1 | 5 | $79.05 | Total: $395.25 |
Data sheet
| Molecular Formula | C27H37Cl2N3O3 |
| Molecular Weight | 522.51 |
| CAS Numbers | 1345675-25-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.Cl.C(COc1ccc(cc1)-c1nc2ccc(OCCCN3CCCC3)cc2o1)CN1CCCC1 |
| References | Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9 mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85[3] 429-40. |
More info
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.