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5HT Receptors
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $37.35 | Total: $3,735.00 |
| 1 | 50 | $43.16 | Total: $2,158.00 |
| 1 | 25 | $50.63 | Total: $1,265.75 |
| 1 | 10 | $59.76 | Total: $597.60 |
| 1 | 5 | $70.55 | Total: $352.75 |
Data sheet
| Molecular Formula | C16H20ClNO |
| Molecular Weight | 277.79 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [H]Cl.C1(COC2CCNCC2)=CC3=C(C=CC=C3)C=C1 |
| References | Lucchelli A, et al. The interaction of antidepressant drugs with central and peripheral [enteric] 5-HT3 and 5-HT4 receptors. Br J Pharmacol. 1995 ; 114[5] 1017-1025. |
More info
Litoxetine HCl is a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI) and mixed 5-hydroxytryptamine antagonist used in the treatment of urinary incontinence. Litoxetine HCl in the absence of antimuscarinic concentrations without antimuscarinic properties (10 nM-1 microM) caused concentration-dependent relaxation of isolated oesophageal muscle mucosa in rats, reducing carbachol tone by up to 37%. Higher concentrations of Litoxetine HCl (3 microM-300 microM) were associated with significant relaxation up to abolition of carbachol tone. The antiarrhythmic activity of Litoxetine HCl, previously demonstrated in the isolated guinea pig intestine, was exerted in the isolated rat oesophageal muscle mucosa at concentrations greater than 1 microM. The 5-HT-releasing effect of Litoxetine HCl could explain the potency of Litoxetine HCl on 5-HT-induced relaxation in untreated rat tissue, which was reversed by pCPA treatment.