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View larger Acotiamide monohydrochloride trihydrate
AT2319
CAS 773092-05-0
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Data sheet
| Molecular Formula | C21H37ClN4O8S |
| Molecular Weight | 541.06 |
| CAS Numbers | 773092-05-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | s1c(nc(c1)C(=O)NCCN(C(C)C)C(C)C)NC(=O)c1c(cc(c(c1)OC)OC)O.O.Cl.O.O |
| References | Kawachi M,et al. Eur J Pharmacol. 2011 Sep;666[1-3] 218-25. |
More info
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.