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> Activators>IMM-H007 (AMPK activator V1)

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IMM-H007 View larger

IMM-H007 (AMPK activator V1)

AOB17217

CAS: 1221412-23-2

Chemical Name: WS070117; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-((3-hydroxyphenyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

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$21.00

$21.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $17.85 Total: $89.25
110 $15.12 Total: $151.20
125 $12.81 Total: $320.25
150 $10.92 Total: $546.00
1100 $9.45 Total: $945.00

Data sheet

Molecular FormulaC22H23N5O8
Molecular Weight485.45
CAS Numbers1221412-23-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical NameWS070117; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(6-((3-hydroxyphenyl)amino)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

More info

Novel lipid-lowering agent, acting as an AMPK activator, increasing ABCA1 protein expression and improving hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis

Core Functional Properties

1. AMPK Activation

  • IMM-H007 activates AMP-activated protein kinase (AMPK), a key energy sensor enzyme that regulates cellular metabolism. PubMed

  • Through AMPK activation, IMM-H007 influences lipid and glucose metabolism, reduces triglyceride accumulation, and improves cholesterol handling in the liver. PubMed

2. Lipid Metabolism & Atherosclerosis

  • IMM-H007 improves cholesterol and triglyceride metabolism by activating AMPKα pathways, enhancing LDL receptor (LDLR) expression and promoting conversion of cholesterol to bile acids. PubMed

  • It reduces hypercholesterolemia and atherosclerotic plaque formation in animal models. PubMed

3. Endothelial Function & Vascular Inflammation

  • It suppresses vascular inflammation in atherosclerosis models, improving endothelial function. PubMed

  • IMM-H007 enhances nitric oxide (NO) production by increasing AMPK-dependent eNOS activity, leading to better endothelial dilation. PubMed

  • It also inhibits pro-inflammatory signaling (e.g., NF-κB and JNK/AP-1 pathways) to reduce inflammation in vascular tissues. PubMed+1

4. Cardiac Fibrosis & TGF-β1 Signaling

  • IMM-H007 attenuates cardiac fibrosis in animal studies, partly via AMPK activation. PubMed

  • It also directly interacts with transforming growth factor β1 (TGF-β1), reducing binding to its receptor and inhibiting downstream Smad2/3 signaling, a key driver of fibrotic gene expression. This effect can occur independently of AMPK. PubMed

5. Regulation of Inflammatory and Signaling Pathways

  • IMM-H007 reduces endothelial inflammation through regulation of NF-κB and JNK/AP-1 signaling. PubMed