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F0911-7667 (HMS607P03)
AOB36115
CAS: 361198-09-6
Chemical Name: (E)-4-(((Benzo[d][1,3]dioxol-5-ylmethyl)amino)methylene)-2-(benzo[d]thiazol-2-yl)-5-(((4-chlorophenyl)thio)methyl)-2,4-dihydro-3H-pyrazol-3-one
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $58.05 | Total: $5,805.00 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 5 | $109.65 | Total: $548.25 |
Data sheet
| Molecular Formula | C26H19ClN4O3S2 |
| Molecular Weight | 535.03 |
| CAS Numbers | 361198-09-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | HMS607P03; F0911-7667 |
| IUPAC/Chemical Name | (E)-4-(((Benzo[d][1,3]dioxol-5-ylmethyl)amino)methylene)-2-(benzo[d]thiazol-2-yl)-5-(((4-chlorophenyl)thio)methyl)-2,4-dihydro-3H-pyrazol-3-one |
| InChl Key | BCCAZPLEJITKJU-CPNJWEJPSA-N |
| InChl Code | InChI=1S/C26H19ClN4O3S2/c27-17-6-8-18(9-7-17)35-14-21-19(13-28-12-16-5-10-22-23(11-16)34-15-33-22)25(32)31(30-21)26-29-20-3-1-2-4-24(20)36-26/h1-11,13,28H,12,14-15H2/b19-13+ |
| SMILES Code | O=C1N(C2=NC3=CC=CC=C3S2)N=C(CSC4=CC=C(Cl)C=C4)/C1=CNCC5=CC=C(OCO6)C6=C5 |
| References | Yao ZQ, Zhang X, Zhen Y, He XY, Zhao S, Li XF, Yang B, Gao F, Guo FY, Fu L, Liu XZ, Duan CZ. A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. Cell Death Dis. 2018 Jul 10;9(7):767. doi: 10.1038/s41419-018-0799-z. PubMed PMID: 29991742; PubMed Central PMCID: PMC6039470. |
More info
Novel activator of SIRT1, inducing autophagic cell death via the AMPK-mTOR-ULK complex and inducing mitophagy by the SIRT1-PINK1-Parkin pathway, downregulating 14-3-3γ, catalase, profilin-1, and HSP90α