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> Activators>F0911-7667 (HMS607P03)

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F0911-7667 (HMS607P03)

AOB36115

CAS: 361198-09-6

Chemical Name: (E)-4-(((Benzo[d][1,3]dioxol-5-ylmethyl)amino)methylene)-2-(benzo[d]thiazol-2-yl)-5-(((4-chlorophenyl)thio)methyl)-2,4-dihydro-3H-pyrazol-3-one

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$129.00

$129.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $109.65 Total: $548.25
110 $92.88 Total: $928.80
125 $78.69 Total: $1,967.25
150 $67.08 Total: $3,354.00
1100 $58.05 Total: $5,805.00

Data sheet

Molecular FormulaC26H19ClN4O3S2
Molecular Weight535.03
CAS Numbers361198-09-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymHMS607P03; F0911-7667
IUPAC/Chemical Name(E)-4-(((Benzo[d][1,3]dioxol-5-ylmethyl)amino)methylene)-2-(benzo[d]thiazol-2-yl)-5-(((4-chlorophenyl)thio)methyl)-2,4-dihydro-3H-pyrazol-3-one
InChl KeyBCCAZPLEJITKJU-CPNJWEJPSA-N
InChl CodeInChI=1S/C26H19ClN4O3S2/c27-17-6-8-18(9-7-17)35-14-21-19(13-28-12-16-5-10-22-23(11-16)34-15-33-22)25(32)31(30-21)26-29-20-3-1-2-4-24(20)36-26/h1-11,13,28H,12,14-15H2/b19-13+
SMILES CodeO=C1N(C2=NC3=CC=CC=C3S2)N=C(CSC4=CC=C(Cl)C=C4)/C1=CNCC5=CC=C(OCO6)C6=C5
ReferencesYao ZQ, Zhang X, Zhen Y, He XY, Zhao S, Li XF, Yang B, Gao F, Guo FY, Fu L, Liu XZ, Duan CZ. A novel small-molecule activator of Sirtuin-1 induces autophagic cell death/mitophagy as a potential therapeutic strategy in glioblastoma. Cell Death Dis. 2018 Jul 10;9(7):767. doi: 10.1038/s41419-018-0799-z. PubMed PMID: 29991742; PubMed Central PMCID: PMC6039470.

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Novel activator of SIRT1, inducing autophagic cell death via the AMPK-mTOR-ULK complex and inducing mitophagy by the SIRT1-PINK1-Parkin pathway, downregulating 14-3-3γ, catalase, profilin-1, and HSP90α