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View larger SIRT6 activator 12q
AOB11999
CAS: 2601734-99-8
Chemical Name: N-Benzhydryl-2-(benzofuran-2-yl)quinoline-4-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Data sheet
| Molecular Formula | C31H22N2O2 |
| Molecular Weight | 454.529 |
| CAS Numbers | 2601734-99-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | SIRT6 activator 12q; SIRT 6 activator 12q; SIRT-6 activator 12q; |
| IUPAC/Chemical Name | N-benzhydryl-2-(benzofuran-2-yl)quinoline-4-carboxamide |
| InChl Key | JNULQPRWYHVXHT-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C31H22N2O2/c34-31(33-30(21-11-3-1-4-12-21)22-13-5-2-6-14-22)25-20-27(32-26-17-9-8-16-24(25)26)29-19-23-15-7-10-18-28(23)35-29/h1-20,30H,(H,33,34) |
| SMILES Code | O=C(C1=CC(C2=CC3=CC=CC=C3O2)=NC4=CC=CC=C14)NC(C5=CC=CC=C5)C6=CC=CC=C6 |
| References | 1) Chen X, Sun W, Huang S, Zhang H, Lin G, Li H, Qiao J, Li L, Yang S. Discovery of Potent Small-Molecule SIRT6 Activators: Structure-Activity Relationship and Anti-Pancreatic Ductal Adenocarcinoma Activity. J Med Chem. 2020 Sep 24;63(18):10474-10495. doi: 10.1021/acs.jmedchem.0c01183. Epub 2020 Sep 9. PMID: 32787077. |
More info
Novel SIRT6 activator, significantly inhibiting the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro and markedly suppressing the tumor growth in a PDAC tumor xenograft model