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RTA-408 (Omaveloxolone)
AOB87284
CAS: 1474034-05-3
Chemical Name: Omaveloxolone; Nrf1-activator-1; N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $56.25 | Total: $5,625.00 |
| 1 | 50 | $65.00 | Total: $3,250.00 |
| 1 | 25 | $76.25 | Total: $1,906.25 |
| 1 | 10 | $90.00 | Total: $900.00 |
| 1 | 5 | $106.25 | Total: $531.25 |
Data sheet
| Molecular Formula | C33H44F2N2O3 |
| Molecular Weight | 554.71 |
| CAS Numbers | 1474034-05-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| Synonym | RTA408; RTA408; RTA-408. Omaveloxolone |
| IUPAC/Chemical Name | N-((4aR,6aR,6bS,12aS,14aR,14bR)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide |
| InChl Key | RJCWBNBKOKFWNY-HGNIWHNWSA-N |
| InChl Code | InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22?,24+,29+,30-,31-,33-/m1/s1 |
| SMILES Code | CC(F)(F)C(N[C@]1(CCC(C)(C[C@@]1([C@]23[H])[H])C)CC[C@@]2(C)[C@]4(C)CCC5C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O)=O |
| References | 1) Alexeev V, Lash E, Aguillard A, Corsini L, Bitterman A, Ward K, Dicker AP, Linnenbach A, Rodeck U. Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Mol Cancer Ther. 2014 Dec;13(12):2968-77. doi: 10.1158/1535-7163.MCT-14-0354. Epub 2014 Nov 14. PubMed PMID: 25398830; PubMed Central PMCID: PMC4258451. |
More info
Novel potent activator of the cytoprotective transcription factor Nrf2, being a robust mitigator of hematopoietic acute radiation syndrome