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Bis-T-23 (Ryngo 1-23)
AOB5869
CAS No: 171674-76-3
Chemical Name: 1,3-Bis(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $35.55 | Total: $3,555.00 |
| 1 | 50 | $41.08 | Total: $2,054.00 |
| 1 | 25 | $48.19 | Total: $1,204.75 |
| 1 | 10 | $56.88 | Total: $568.80 |
| 1 | 5 | $67.15 | Total: $335.75 |
Data sheet
| Molecular Formula | C23H20N4O8 |
| Molecular Weight | 480.43 |
| CAS Numbers | 171674-76-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Ryngo-1-23; Ryngo 123; Ryngo 1 23; Bis-T-23; Bis T-23; Bis T 23; Bis-T 23; AG 1717; AG1717; AG-1717 |
| IUPAC/Chemical Name | (2E,2'E)-N,N'-(propane-1,3-diyl)bis(2-cyano-3-(3,4,5-trihydroxyphenyl)acrylamide) |
| InChl Key | Key: AAPVOSBVTLGGOU-VHUAAIQRSA-N |
| InChl Code | InChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+ |
| SMILES Code | O=C(NCCCNC(/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1)=O)/C(C#N)=C/C2=CC(O)=C(O)C(O)=C2 |
| References | 1) Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun;93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17. Review. PubMed PMID: 29678354; PubMed Central PMCID: PMC5967993. 2) Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H. O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. Nephrol Dial Transplant. 2017 Sep 1;32(9):1477-1487. doi: 10.1093/ndt/gfw463. PubMed PMID: 28339907. |
More info
Promoter of actin-dependent dynamin oligomerization, increasing actin polymerization in injured podocytes