ADC Linker

Mc-Val-Cit-PAB-Cl View larger

Mc-Val-Cit-PAB-Cl

AT18321

CAS 1639351-92-0

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$101.00

$101.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $45.45 Total: $4,545.00
150 $52.52 Total: $2,626.00
125 $61.61 Total: $1,540.25
110 $72.72 Total: $727.20
15 $85.85 Total: $429.25

Data sheet

Molecular FormulaC28H39ClN6O6
Molecular Weight591.1
CAS Numbers1639351-92-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES Code[C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O
ReferencesStaben LR, et al. Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors. ACS Med Chem Lett. 2017 Sep 5;8[10] 1037-1041.

More info

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.