Allosteric

UoS-12258 View larger

UoS-12258

AOB17747

CAS: 875927-64-3

Chemical Name: N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

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$19.00

$19.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $8.55 Total: $855.00
150 $9.88 Total: $494.00
125 $11.59 Total: $289.75
110 $13.68 Total: $136.80
15 $16.15 Total: $80.75

Data sheet

Molecular FormulaC17H19FN2O2S
Molecular Weight334.41
CAS Numbers875927-64-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymUoS 12258; UoS12258; UoS-12258
IUPAC/Chemical NameN-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
InChl KeyQXQSUBKWSHMXDP-INIZCTEOSA-N
InChl CodeInChI=1S/C17H19FN2O2S/c1-11(2)23(21,22)20-16-8-13-4-3-12(7-15(13)9-16)14-5-6-17(18)19-10-14/h3-7,10-11,16,20H,8-9H2,1-2H3/t16-/m0/s1
SMILES CodeCC(S(=O)(N[C@H]1CC2=CC=C(C3=CN=C(C=C3)F)C=C2C1)=O)C
References1) Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID: 20614889

2) Ward et al (2017) Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br.J.Pharmacol. 174 370 PMID: 28009436
PubChem ID46398805

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Novel positive allosteric modulator (PAM) of AMPA receptors