Alzheimer's Disease

RS-0406 View larger

RS-0406

AOB37575

CAS: 530112-00-6

Chemical Name: 3,3'-(Pyridazine-3,6-diylbis(azanediyl))diphenol

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$39.00

$39.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $17.55 Total: $1,755.00
150 $20.28 Total: $1,014.00
125 $23.79 Total: $594.75
110 $28.08 Total: $280.80
15 $33.15 Total: $165.75

Data sheet

Molecular FormulaC16H14N4O2
Molecular Weight294.31
CAS Numbers530112-00-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymRS-0406; RS0406; Phenol.
IUPAC/Chemical Name3,3'-(Pyridazine-3,6-diylbis(azanediyl))diphenol
InChl KeyGYNDFOLSPPBBIK-UHFFFAOYSA-N
InChl CodeInChI=1S/C16H14N4O2/c21-13-5-1-3-11(9-13)17-15-7-8-16(20-19-15)18-12-4-2-6-14(22)10-12/h1-10,21-22H,(H,17,19)(H,18,20)
SMILES CodeOC1=CC=CC(NC2=NN=C(NC3=CC(O)=CC=C3)C=C2)=C1
References1) Kalhor HR, Jabbari MP. Inhibition Mechanisms of a Pyridazine-Based Amyloid Inhibitor: As a β-Sheet Destabilizer and a Helix Bridge Maker. J Phys Chem B. 2017 Aug 17;121(32):7633-7645.

2) Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM. Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br J Pharmacol. 2012 Sep;167(2):383-92.

3) O'Hare E, Scopes DI, Treherne JM, Norwood K, Spanswick D, Kim EM. RS-0406 arrests amyloid-beta oligomer-induced behavioural deterioration in vivo. Behav Brain Res. 2010 Jun 26;210(1):32-7.

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Novel amyloid inhibitor, acting as a β-sheet destabilizer and a helix bridge maker

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