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Alzheimer's Disease
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RS-0406
AOB37575
CAS: 530112-00-6
Chemical Name: 3,3'-(Pyridazine-3,6-diylbis(azanediyl))diphenol
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $17.55 | Total: $1,755.00 |
| 1 | 50 | $20.28 | Total: $1,014.00 |
| 1 | 25 | $23.79 | Total: $594.75 |
| 1 | 10 | $28.08 | Total: $280.80 |
| 1 | 5 | $33.15 | Total: $165.75 |
Data sheet
| Molecular Formula | C16H14N4O2 |
| Molecular Weight | 294.31 |
| CAS Numbers | 530112-00-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | RS-0406; RS0406; Phenol. |
| IUPAC/Chemical Name | 3,3'-(Pyridazine-3,6-diylbis(azanediyl))diphenol |
| InChl Key | GYNDFOLSPPBBIK-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C16H14N4O2/c21-13-5-1-3-11(9-13)17-15-7-8-16(20-19-15)18-12-4-2-6-14(22)10-12/h1-10,21-22H,(H,17,19)(H,18,20) |
| SMILES Code | OC1=CC=CC(NC2=NN=C(NC3=CC(O)=CC=C3)C=C2)=C1 |
| References | 1) Kalhor HR, Jabbari MP. Inhibition Mechanisms of a Pyridazine-Based Amyloid Inhibitor: As a β-Sheet Destabilizer and a Helix Bridge Maker. J Phys Chem B. 2017 Aug 17;121(32):7633-7645. 2) Scopes DI, O'Hare E, Jeggo R, Whyment AD, Spanswick D, Kim EM, Gannon J, Amijee H, Treherne JM. Aβ oligomer toxicity inhibitor protects memory in models of synaptic toxicity. Br J Pharmacol. 2012 Sep;167(2):383-92. 3) O'Hare E, Scopes DI, Treherne JM, Norwood K, Spanswick D, Kim EM. RS-0406 arrests amyloid-beta oligomer-induced behavioural deterioration in vivo. Behav Brain Res. 2010 Jun 26;210(1):32-7. |
More info
Novel amyloid inhibitor, acting as a β-sheet destabilizer and a helix bridge maker
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