Alzheimer's Disease

F-cromolyn View larger

F-cromolyn

AOB19437

CAS: 1236211-78-1

 

Chemical Name: 5,5'-((2-Fluoropropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid)

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$169.00

$169.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $76.05 Total: $7,605.00
150 $87.88 Total: $4,394.00
125 $103.09 Total: $2,577.25
110 $121.68 Total: $1,216.80
15 $143.65 Total: $718.25

Data sheet

Molecular FormulaC23H15FO10
Molecular Weight470.35
CAS Numbers1236211-78-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymFcromolyn
IUPAC/Chemical Name5,5'-((2-Fluoropropane-1,3-diyl)bis(oxy))bis(4-oxo-4H-chromene-2-carboxylic acid)
References1) Timothy Shoup et al., Fluorinated Cromolyn Derivatives for Potential Alzheimer’s Disease Treatment, Journal of Nuclear Medicine Vol. 60, Issue supplement 1 May 1, 2019

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Novel potent anti-Alzheimer agent, reducing secretion of collagen XVIII, fibronectin, and tenascin-c, also reducing pro-inflammatory proteins PLP1, PELP1, HSP90, IL-2, GRO-α, Eotaxin, and VEGF-Α, while promoting secretion of anti-inflammatory IL-4 in HMC3 microglia, targeting multiple proteins upstream of PI3K/Akt/mTOR, NF-κB, and GSK-3β signaling pathways to affect cytokine, chemokine, and fibrosis-related protein expression