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> Alzheimer's Disease>Dihydroergocristine mesylate

Alzheimer's Disease

Dihydroergocristine mesylate View larger

Dihydroergocristine mesylate

AT11043

CAS 24730-10-7

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$41.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $34.85 Total: $174.25
110 $29.52 Total: $295.20
125 $25.01 Total: $625.25
150 $21.32 Total: $1,066.00
1100 $18.45 Total: $1,845.00

Data sheet

Molecular FormulaC36H45N5O8S
Molecular Weight707.84
CAS Numbers24730-10-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCS(O)(=O)=O.[H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)N1C(=O)[C@](NC(=O)[C@H]3CN(C)[C@]4([H])Cc5c[nH]c6cccc(c56)[C@@]4([H])C3)(O[C@@]21O)C(C)C
ReferencesLei X, et al. The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-? peptides. Sci Rep. 2015 Nov 16;5 16541.

More info

Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of ?-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-? peptides, binds directly to ?-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 ?M, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.