Alzheimer's Disease

CHF 5074 View larger

CHF 5074

AOB5325

CAS No:749269-83-8

Chemical Name: CHF5074; 1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid

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$19.00

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $8.55 Total: $855.00
150 $9.88 Total: $494.00
125 $11.59 Total: $289.75
110 $13.68 Total: $136.80
15 $16.15 Total: $80.75

Data sheet

Molecular Formula C16H11Cl2FO2
Molecular Weight 325.16
CAS Numbers 749269-83-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Stock Solution Guide10 mMol/3.25 mg/1 mL of DMSO
Purity98% by HPLC
SynonymCHF-5074; CHF5074; CHF 5074; CSP-1103; CSP 1103; CSP1103
IUPAC/Chemical Name 1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid
InChl KeyLIYLTQQDABRNRX-UHFFFAOYSA-N
InChl CodeInChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21)
SMILES CodeOC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O
References1) Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830.

2) Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.

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a γ-secretase modulator