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View larger CHF 5074
AOB5325
CAS No:749269-83-8
Chemical Name: CHF5074; 1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $16.15 | Total: $80.75 |
| 1 | 10 | $13.68 | Total: $136.80 |
| 1 | 25 | $11.59 | Total: $289.75 |
| 1 | 50 | $9.88 | Total: $494.00 |
| 1 | 100 | $8.55 | Total: $855.00 |
Data sheet
| Molecular Formula | C16H11Cl2FO2 |
| Molecular Weight | 325.16 |
| CAS Numbers | 749269-83-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Stock Solution Guide | 10 mMol/3.25 mg/1 mL of DMSO |
| Purity | 98% by HPLC |
| Synonym | CHF-5074; CHF5074; CHF 5074; CSP-1103; CSP 1103; CSP1103 |
| IUPAC/Chemical Name | 1-(3',4'-Dichloro-2-fluorobiphenyl-4-yl)cyclopropanecarboxylic acid |
| InChl Key | LIYLTQQDABRNRX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C16H11Cl2FO2/c17-12-4-1-9(7-13(12)18)11-3-2-10(8-14(11)19)16(5-6-16)15(20)21/h1-4,7-8H,5-6H2,(H,20,21) |
| SMILES Code | OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O |
| References | 1) Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830. 2) Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90. |
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a γ-secretase modulator