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View larger Cefoperazone
AT6437
CAS 62893-19-0
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Data sheet
| Molecular Formula | C25H27N9O8S2 |
| Molecular Weight | 645.67 |
| CAS Numbers | 62893-19-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(O)(=O)C=1N2[C@@]([C@H](NC([C@H](NC(=O)N3C(=O)C(=O)N(CC)CC3)C4=CC=C(O)C=C4)=O)C2=O)(SCC1CSC=5N(C)N=NN5)[H] |
| References | Kato Y, et al. Drug Metab Dispos, 2008, 36[6], 1088-1096. |
More info
Cefoperazone (Medocef) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. It can inhibit rMrp2-mediated [3H]E217?G uptake (IC50: 199 ?M).