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View larger Naftifine hydrochloride
AT1543
CAS 65473-14-5
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Data sheet
| Molecular Formula | C21H22ClN |
| Molecular Weight | 323.86 |
| CAS Numbers | 65473-14-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.CN(CC=Cc1ccccc1)Cc1cccc2ccccc12 |
| References | Georgopoulos A, et al. Antimicrob Agents Chemother, 1981, 19[3], 386-389. |
More info
Naftifine Hydrochloride is the hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2, 3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride (Naftifine HCl) can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved.
