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View larger Leptomycin B
AT15735
CAS 87081-35-4
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $153.85 | Total: $769.25 |
| 1 | 10 | $130.32 | Total: $1,303.20 |
| 1 | 25 | $110.41 | Total: $2,760.25 |
| 1 | 50 | $94.12 | Total: $4,706.00 |
| 1 | 100 | $81.45 | Total: $8,145.00 |
Data sheet
| Molecular Formula | C33H48O6 |
| Molecular Weight | 540.73 |
| CAS Numbers | 87081-35-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCC(C=C[C@H]1OC(=O)C=C[C@@H]1C)=C[C@H](C)CC=CC(C)=C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CC(C)=CC(O)=O |
| References | Kudo N, et al. Leptomycin B inactivates CRM1exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96[16] 9112-7. |
More info
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1exportin 1 by covalent modification at a cysteine residue.