Antiviral

HBF-0259 View larger

HBF-0259

AT27527

CAS 957011-15-3

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$27.00

$27.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $12.15 Total: $1,215.00
150 $14.04 Total: $702.00
125 $16.47 Total: $411.75
110 $19.44 Total: $194.40
15 $22.95 Total: $114.75

Data sheet

Molecular FormulaC16H12Cl2FN5
Molecular Weight364.2
CAS Numbers957011-15-3
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeFc1cccc(Cl)c1C1CC(N=C2N=NNN12)c1ccc(Cl)cc1
ReferencesYu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen [HBsAg] secretion. J Med Chem. 2011 Aug 25;54[16] 5660-70. doi 10.1021jm200696v. Epub 2011 Aug 2. PubMed PMID 21786803; PubMed Central PMCID PMC3158247.

More info

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 ?M and a CC50 value of >50 ?M in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.