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Antiviral
- Protein Control Ligand
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- p18
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- Biomarkers and Buffer Solutions
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- SARS-CoV
View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Data sheet
| Molecular Formula | C16H12Cl2FN5 |
| Molecular Weight | 364.2 |
| CAS Numbers | 957011-15-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Fc1cccc(Cl)c1C1CC(N=C2N=NNN12)c1ccc(Cl)cc1 |
| References | Yu W, Goddard C, Clearfield E, Mills C, Xiao T, Guo H, Morrey JD, Motter NE, Zhao K, Block TM, Cuconati A, Xu X. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen [HBsAg] secretion. J Med Chem. 2011 Aug 25;54[16] 5660-70. doi 10.1021jm200696v. Epub 2011 Aug 2. PubMed PMID 21786803; PubMed Central PMCID PMC3158247. |
More info
HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 ?M and a CC50 value of >50 ?M in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.