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View larger Tenofovir exalidex
AT28946
CAS 911208-73-6
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $28.05 | Total: $140.25 |
| 1 | 10 | $23.76 | Total: $237.60 |
| 1 | 25 | $20.13 | Total: $503.25 |
| 1 | 50 | $17.16 | Total: $858.00 |
| 1 | 100 | $14.85 | Total: $1,485.00 |
Data sheet
| Molecular Formula | C28H52N5O5P |
| Molecular Weight | 569.72 |
| CAS Numbers | 911208-73-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)C)N1C=2C(N=C1)=C(N)N=CN2 |
| References | Lanier ER, et al. Development of hexadecyloxypropyl tenofovir [CMX157] for treatment of infection caused by wild-type and nucleosidenucleotide-resistant HIV. Antimicrob Agents Chemother. 2010;54[7] 2901-2909. |
More info
Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleosidenucleotide analogs. It effectively inhibits all major HIV-1 and HIV-2 subtypes in fresh human PBMCs, as well as all evaluated HIV-1 strains in monocyte-derived macrophages, displaying EC50 values between 0.2 and 7.2 nM. Oral administration of CMX157 shows no apparent toxicity. Additionally, Tenofovir exalidex exhibits antiviral properties against HBV.