Antiviral

Tenofovir exalidex View larger

Tenofovir exalidex

AT28946

CAS 911208-73-6

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$33.00

$33.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $14.85 Total: $1,485.00
150 $17.16 Total: $858.00
125 $20.13 Total: $503.25
110 $23.76 Total: $237.60
15 $28.05 Total: $140.25

Data sheet

Molecular FormulaC28H52N5O5P
Molecular Weight569.72
CAS Numbers911208-73-6
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeC([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)C)N1C=2C(N=C1)=C(N)N=CN2
ReferencesLanier ER, et al. Development of hexadecyloxypropyl tenofovir [CMX157] for treatment of infection caused by wild-type and nucleosidenucleotide-resistant HIV. Antimicrob Agents Chemother. 2010;54[7] 2901-2909.

More info

Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleosidenucleotide analogs. It effectively inhibits all major HIV-1 and HIV-2 subtypes in fresh human PBMCs, as well as all evaluated HIV-1 strains in monocyte-derived macrophages, displaying EC50 values between 0.2 and 7.2 nM. Oral administration of CMX157 shows no apparent toxicity. Additionally, Tenofovir exalidex exhibits antiviral properties against HBV.