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View larger Pradefovir
AT28449
CAS 625095-60-5
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $171.70 | Total: $858.50 |
| 1 | 10 | $145.44 | Total: $1,454.40 |
| 1 | 25 | $123.22 | Total: $3,080.50 |
| 1 | 50 | $105.04 | Total: $5,252.00 |
| 1 | 100 | $90.90 | Total: $9,090.00 |
Data sheet
| Molecular Formula | C17H19ClN5O4P |
| Molecular Weight | 423.79 |
| CAS Numbers | 625095-60-5 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(COCP1(=O)O[C@@H](CCO1)C2=CC(Cl)=CC=C2)N3C=4C(N=C3)=C(N)N=CN4 |
| References | Xiao Q, Wang D, Yang W, Chen L, Ding Y, Yang J. Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022 133-40. doi 10.1016j.jchromb.2016.04.019. Epub 2016 Apr 11. PubMed PMID 27089519. |
More info
Pradefovir (Remofovir) is a reverse transcriptase inhibitor potentially for treatment of chronic HBV infection. Pradefovir is also a liver-targeted prodrug of adefovir. After metabolic activation, Pradefovir was converted to PMEA (9-(2-phosphonylmethoxyethyl)adenine) in human liver microsomes with a K(m) of 60 microM, a maximum rate of metabolism of 228 pmolminmg protein, and an intrinsic clearance of about 359 mlmin.