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> Apoptosis>Patupilone (Epothilone B)

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Patupilone (Epothilone B) View larger

Patupilone (Epothilone B)

AOB2930

CAS: 152044-54-7

 

Chemical Name: (-)-Epothilone B; Patupilone; EPO906; (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $12.75 Total: $63.75
110 $10.80 Total: $108.00
125 $9.15 Total: $228.75
150 $7.80 Total: $390.00
1100 $6.75 Total: $675.00

Data sheet

Molecular FormulaC27H41NO6S
Molecular Weight507.68
CAS Numbers152044-54-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymEPO906; EPO-906; EPO 906; EPO 906A; EPO B; (-)-Epothilone B; patupilone.
IUPAC/Chemical Name(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
InChl KeyQXRSDHAAWVKZLJ-PVYNADRNSA-N
InChl CodeInChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
SMILES CodeC/C([C@@H](OC(C[C@H](O)C1(C)C)=O)C[C@H](O2)[C@@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O)=CC3=CSC(C)=N3
References1) Rogalska A, Bukowska B, Marczak A. Caspases and ROS - dependent mechanism of action mediated by combination of WP 631 and epothilone B. Anticancer Agents Med Chem. 2014;14(9):1261-70. PubMed PMID: 24913659.

2) Rogalska A, Gajek A, Marczak A. Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells. Toxicol In Vitro. 2014 Jun;28(4):675-83. doi: 10.1016/j.tiv.2014.02.007. Epub 2014 Feb 26. PubMed PMID: 24583341.

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Antitumor agent, stabilizing microtubule (MT) and inducing extrinsic pathway of apoptosis