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Apoptosis
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View larger MPTP hydrochloride
AT4081
CAS 23007-85-4
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Data sheet
| Molecular Formula | C12H16ClN |
| Molecular Weight | 209.72 |
| CAS Numbers | 23007-85-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.CN1CCC(=CC1)c1ccccc1 |
| References | Qureshi HY, et al. Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP] and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011 Feb 18;286[7] 5055-68. |
More info
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.