Apoptosis

MPTP hydrochloride View larger

MPTP hydrochloride

AT4081

CAS 23007-85-4

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$26.00

$26.00 per 5 mg

Data sheet

Molecular FormulaC12H16ClN
Molecular Weight209.72
CAS Numbers23007-85-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCl.CN1CCC(=CC1)c1ccccc1
ReferencesQureshi HY, et al. Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP] and alpha-synuclein mutations promote Tau protein phosphorylation at Ser262 and destabilize microtubule cytoskeleton in vitro. J Biol Chem. 2011 Feb 18;286[7] 5055-68.

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MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in the construction of animal models of Parkinson's disease.