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> Apoptosis>AZD5582 TFA

Apoptosis

AZD5582 TFA View larger

AZD5582 TFA

AT36201L

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$43.00

$43.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $36.55 Total: $182.75
110 $30.96 Total: $309.60
125 $26.23 Total: $655.75
150 $22.36 Total: $1,118.00
1100 $19.35 Total: $1,935.00

Data sheet

Molecular FormulaC60H79F3N8O10
Molecular Weight1129.31
CAS Numbers2041075-86-7
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO=C([C@H]1N(CCC1)C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)N[C@H]3C4=CC=CC=C4C[C@H]3OCC#CC#CCO[C@H]5[C@H](C6=CC=CC=C6C5)NC([C@H]7N(CCC7)C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)=O.OC(C(F)(F)F)=O
ReferencesHennessy EJ, et al. Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer [AZD5582]. J Med Chem. 2013;56[24] 9897-9919.

More info

AZD5582 TFA is a potent IAP antagonist that binds to the BIR3 domain of cIAP1, cIAP2, and XIAP with IC50 values of 15, 21, and 15 nM, respectively.AZD5582 TFA induces apoptosis.