Apoptosis

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Vamotinib

AT63746

CAS 1416241-23-0

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$113.00

$113.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $50.85 Total: $5,085.00
150 $58.76 Total: $2,938.00
125 $68.93 Total: $1,723.25
110 $81.36 Total: $813.60
15 $96.05 Total: $480.25

Data sheet

Molecular FormulaC29H27F3N6O
Molecular Weight532.56
CAS Numbers1416241-23-0
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nnc4ccccn34)cc2C(F)(F)F)CC1
ReferencesMian AA, et al. PF-114, a potent and selective inhibitor of native and mutated BCRABL is active against Philadelphia chromosome-positive [Ph+] leukemias harboring the T315I mutation. Leukemia. 2015 May;29[5] 1104-14.

More info

Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCRABL and BCRABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.