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Apoptosis
- Protein Control Ligand
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View larger Vamotinib
AT63746
CAS 1416241-23-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $96.05 | Total: $480.25 |
| 1 | 10 | $81.36 | Total: $813.60 |
| 1 | 25 | $68.93 | Total: $1,723.25 |
| 1 | 50 | $58.76 | Total: $2,938.00 |
| 1 | 100 | $50.85 | Total: $5,085.00 |
Data sheet
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 |
| CAS Numbers | 1416241-23-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3nnc4ccccn34)cc2C(F)(F)F)CC1 |
| References | Mian AA, et al. PF-114, a potent and selective inhibitor of native and mutated BCRABL is active against Philadelphia chromosome-positive [Ph+] leukemias harboring the T315I mutation. Leukemia. 2015 May;29[5] 1104-14. |
More info
Vamotinib (PF-114) is an orally active and specific tyrosine kinase inhibitor with antiproliferative and antitumour activity.Vamotinib inhibits the phosphorylation of BCRABL and BCRABL-T315I, which promotes apoptosis. Vamotinib is used to study drug-resistant Philadelphia chromosome-positive (Ph+) leukaemia and Alzheimer's disease.