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View larger ZNL 02-096
AT41163
CAS 2414418-49-6
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $190.40 | Total: $952.00 |
| 1 | 10 | $161.28 | Total: $1,612.80 |
| 1 | 25 | $136.64 | Total: $3,416.00 |
| 1 | 50 | $116.48 | Total: $5,824.00 |
| 1 | 100 | $100.80 | Total: $10,080.00 |
Data sheet
| Molecular Formula | C42H45N11O6 |
| Molecular Weight | 799.88 |
| CAS Numbers | 2414418-49-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(C=C)N1N(C=2C(C1=O)=CN=C(NC3=CC=C(C=C3)N4CCN(CCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)CC4)N2)C=8N=C(C(C)(C)O)C=CC8 |
| References | Nathanael S G, et al. Degraders of wee1 kinase. WO2020069105A1. |
More info
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL 02-096 induces degradation of Wee1 and accumulation of DNA damage in MOLT-4 cells in vitro, In vitro in MOLT-4 cells, ZNL 02-096 induced Wee1 degradation, accumulation of DNA damage, cell cycle arrest in G2M phase and apoptosis.ZNL 02-096 showed anti-proliferative effects in 300 cancer cell lines.