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Apoptosis
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View larger Simmiparib
AT63228
CAS 1551355-46-4
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $231.20 | Total: $1,156.00 |
| 1 | 10 | $195.84 | Total: $1,958.40 |
| 1 | 25 | $165.92 | Total: $4,148.00 |
| 1 | 50 | $141.44 | Total: $7,072.00 |
| 1 | 100 | $122.40 | Total: $12,240.00 |
Data sheet
| Molecular Formula | C23H18F4N6O2 |
| Molecular Weight | 486.42 |
| CAS Numbers | 1551355-46-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC1CN(Cc2nnc(n12)C(F)(F)F)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F |
| References | Yuan B, et al. Poly[ADP-ribose]polymerase [PARP] inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials. Cancer Lett. 2017 Feb 1;386 47-56. |
More info
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient cells, thereby contributing to apoptosis.Simmiparib has been used for study Parkinson's disease, Alzheimer's disease, breast cancer, and melanoma.