Apoptosis

Trk-IN-9 View larger

Trk-IN-9

AT62806

CAS 2758623-12-8

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$81.00

$81.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $36.45 Total: $3,645.00
150 $42.12 Total: $2,106.00
125 $49.41 Total: $1,235.25
110 $58.32 Total: $583.20
15 $68.85 Total: $344.25

Data sheet

Molecular FormulaC23H24ClFN6O
Molecular Weight454.93
CAS Numbers2758623-12-8
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeN(C=1N=C(NCC2=CC(F)=CC=C2)C(Cl)=CN1)C3=CC(C(N[C@@H]4CCCNC4)=O)=CC=C3
ReferencesWu T, et al. Rational drug design to explore the structure-activity relationship [SAR] of TRK inhibitors with 2,4-diaminopyrimidine scaffold. Eur J Med Chem. 2022;230 114096.

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Trk-IN-9 (Compound 12) is a potent inhibitor of TRK that inhibits the proliferation of Km-12 cell lines and induces apoptosis in a concentration-dependent manner. It also inhibits TRK phosphorylation and blocks downstream pathways, showing potential for NTRK fusion cancer research.