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Apoptosis
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View larger ULK1-IN-2
AT63343
CAS 2497409-01-3
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Data sheet
| Molecular Formula | C19H16BrFN4O6 |
| Molecular Weight | 495.26 |
| CAS Numbers | 2497409-01-3 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O(C)C1=C(OC)C=C(NC=2N=C(OC3=C(F)C=C(N(=O)=O)C=C3)C(Br)=CN2)C=C1OC |
| References | Sun D, Yang Z, Zhen Y, et al. Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer. Eur J Med Chem. 2020;208 112782. |
More info
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.ULK1-IN-2 has high cytotoxicity against cancer cells, with an IC50 value of 1.94 ?M against A549 cells.ULK1-IN-2 can be used for the study of non-small-cell lung cancer.