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View larger 5-Hydroxy-1-methylhydantoin
AT28222
CAS 84210-26-4
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $56.70 | Total: $5,670.00 |
| 1 | 50 | $65.52 | Total: $3,276.00 |
| 1 | 25 | $76.86 | Total: $1,921.50 |
| 1 | 10 | $90.72 | Total: $907.20 |
| 1 | 5 | $107.10 | Total: $535.50 |
Data sheet
| Molecular Formula | C4H6N2O3 |
| Molecular Weight | 130.1 |
| CAS Numbers | 84210-26-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC1N(C)C(=O)NC1=O |
| References | Ienaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH [5-hydroxy-1-methylhydantoin; NZ-419], modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun;34[3] 195-200. |
More info
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.