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> G Protein-Coupled Receptor Ligands>Bradykinin Receptor>5-Hydroxy-1-methylhydantoin

Bradykinin Receptor

5-Hydroxy-1-methylhydantoin View larger

5-Hydroxy-1-methylhydantoin

AT28222

CAS 84210-26-4

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$126.00

$126.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $107.10 Total: $535.50
110 $90.72 Total: $907.20
125 $76.86 Total: $1,921.50
150 $65.52 Total: $3,276.00
1100 $56.70 Total: $5,670.00

Data sheet

Molecular FormulaC4H6N2O3
Molecular Weight130.1
CAS Numbers84210-26-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeOC1N(C)C(=O)NC1=O
ReferencesIenaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH [5-hydroxy-1-methylhydantoin; NZ-419], modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun;34[3] 195-200.

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5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to confer renoprotection by inhibiting the progression of chronic kidney disease in rats. 5-Hydroxy-1-methylhydantoin is a novel anti-oxidant drug completely suppressed the expression of B2-kinin receptors (B2KR) in response to high glucose (25 mM) stimulation in VSMC and was also shown to attenuate the effects of BK on VSMC remodeling. 5-Hydroxy-1-methylhydantoin inhibited the BK-induced increase in MAPK phosphorylation and attenuated the increase in connective tissue growth factor (CTGF) protein levels in VSMC. These findings suggest that 5-Hydroxy-1-methylhydantoin may confer vascular protection against high glucose concentrations and BK-stimulation to ameliorate vascular injury and remodeling through its anti-oxidant properties.