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GAL-021
AOB37397
CAS No: 1380341-99-0
Chemical Name: 6-(Methoxy(methyl)amino)-N2,N4-dipropyl-1,3,5-triazine-2,4-diamine
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HOW TO ORDER
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.20 | Total: $720.00 |
| 1 | 50 | $8.32 | Total: $416.00 |
| 1 | 25 | $9.76 | Total: $244.00 |
| 1 | 10 | $11.52 | Total: $115.20 |
| 1 | 5 | $13.60 | Total: $68.00 |
Data sheet
| Molecular Formula | C11H22N6O |
| Molecular Weight | 254.338 |
| CAS Numbers | 1380341-99-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| InChl Key | FJNLCHNQVJVCPY-UHFFFAOYSA-N |
More info
Blocker of large conductance calcium-activated potassium channel (BKCa-channel)
REFERENCE:
1: Golder FJ, Dax S, Baby SM, Gruber R, Hoshi T, Ideo C, Kennedy A, Peng S, Puskovic V, Ritchie D, Woodward R, Wardle RL, Van Scott MR, Mannion JC, MacIntyre DE. Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator. Anesthesiology. 2015 Nov;123(5):1093-104. doi: 10.1097/ALN.0000000000000844. PubMed PMID: 26352381.
2: Dallas ML, Peers C, Golder FJ, Baby S, Gruber R, MacIntyre DE. GAL-021 and GAL-160 are Efficacious in Rat Models of Obstructive and Central Sleep Apnea and Inhibit BKCa in Isolated Rat Carotid Body Glomus Cells. Adv Exp Med Biol. 2015;860:361-70. doi: 10.1007/978-3-319-18440-1_41. PubMed PMID: 26303501.
3: McLeod JF, Leempoels JM, Peng SX, Dax SL, Myers LJ, Golder FJ. GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers. Br J Anaesth. 2014 Nov;113(5):875-83. doi: 10.1093/bja/aeu182. PubMed PMID: 24989775.
4: Roozekrans M, Olofsen E, van der Schrier R, van Gerven J, Peng S, McLeod J, Dahan A. Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteers. Clin Pharmacol Ther. 2015 Jun;97(6):641-9. doi: 10.1002/cpt.99. PubMed PMID: 25704491.
5: Roozekrans M, van der Schrier R, Okkerse P, Hay J, McLeod JF, Dahan A. Two studies on reversal of opioid-induced respiratory depression by BK-channel blocker GAL021 in human volunteers. Anesthesiology. 2014 Sep;121(3):459-68. doi: 10.1097/ALN.0000000000000367. PubMed PMID: 25222672.
6: van der Schier R, Roozekrans M, van Velzen M, Dahan A, Niesters M. Opioid-induced respiratory depression: reversal by non-opioid drugs. F1000Prime Rep. 2014 Sep 4;6:79. doi: 10.12703/P6-79. Review. PubMed PMID: 25343036; PubMed Central PMCID: PMC4173639.
7: Golder FJ, Hewitt MM, McLeod JF. Respiratory stimulant drugs in the post-operative setting. Respir Physiol Neurobiol. 2013 Nov 1;189(2):395-402. doi: 10.1016/j.resp.2013.06.010. Review. PubMed PMID: 23791825.
8: Cotten JF. The latest pharmacologic ventilator. Anesthesiology. 2014 Sep;121(3):442-4. doi: 10.1097/ALN.0000000000000368. PubMed PMID: 25222671; PubMed Central PMCID: PMC4166568.
9: Xie Y, Puscheck EE, Rappolee DA. Effects of SAPK/JNK inhibitors on preimplantation mouse embryo development are influenced greatly by the amount of stress induced by the media. Mol Hum Reprod. 2006 Apr;12(4):217-24. PubMed PMID: 16574700.