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GI181771X
AOB4566
CAS: 305366-98-7
Chemical Name: GI-181771; GI-181771X; 3-[[[[(3S)-2,3,4,5-Tetrahydro-1-[2-[(1-methylethyl)phenyl-amino]-2-oxoethyl]-2,4-dioxo-5-phenyl-1H-1,5-benzodiazepin-3-yl]amino]-carbonyl]amino]-benzoic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $67.05 | Total: $6,705.00 |
| 1 | 50 | $77.48 | Total: $3,874.00 |
| 1 | 25 | $90.89 | Total: $2,272.25 |
| 1 | 10 | $107.28 | Total: $1,072.80 |
| 1 | 5 | $126.65 | Total: $633.25 |
Data sheet
| Molecular Formula | C34H31N5O6 |
| Molecular Weight | 605.64 |
| CAS Numbers | 305366-98-7 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Purity | 99% (HPLC) |
| Synonym | GI-181771X; GI181771X; GI 181771X; GSKI 181771X;GSKI-181771X; GSKI181771X. |
| IUPAC/Chemical Name | (S)-3-(3-(1-(2-(isopropyl(phenyl)amino)-2-oxoethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)ureido)benzoic acid |
| InChl Key | CABBMMXFOOZVMS-PMERELPUSA-N |
| InChl Code | InChI=1S/C34H31N5O6/c1-22(2)38(25-14-5-3-6-15-25)29(40)21-37-27-18-9-10-19-28(27)39(26-16-7-4-8-17-26)32(42)30(31(37)41)36-34(45)35-24-13-11-12-23(20-24)33(43)44/h3-20,22,30H,21H2,1-2H3,(H,43,44)(H2,35,36,45)/t30-/m0/s1 |
| SMILES Code | CC(C)N(c1ccccc1)C(=O)CN2c3ccccc3N(C(=O)[C@H](C2=O)NC(=O)Nc4cccc(c4)C(=O)O)c5ccccc5 |
| References | 1) Myer JR, Romach EH, Elangbam CS. Species- and dose-specific pancreatic responses and progression in single- and repeat-dose studies with GI181771X: a novel cholecystokinin 1 receptor agonist in mice, rats, and monkeys. Toxicol Pathol. 2014 Jan;42(1):260-74. doi: 10.1177/0192623313506792. Epub 2013 Oct 31. PubMed PMID: 24178573. 2) Harikumar KG, Cawston EE, Lam PC, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ. Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. J Biol Chem. 2013 Jul 19;288(29):21082-95. doi: 10.1074/jbc.M113.480715. Epub 2013 Jun 10. PubMed PMID: 23754289; PubMed Central PMCID: PMC3774375. |
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Novel potent and selective oral CCK-1 agonist