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Cell Inhibition
- Protein Control Ligand
- Pathway Inhibitors
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- Protease
- Synthase
- p18
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View larger Edicotinib
AT15199
CAS 1142363-52-7
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $45.90 | Total: $229.50 |
| 1 | 10 | $38.88 | Total: $388.80 |
| 1 | 25 | $32.94 | Total: $823.50 |
| 1 | 50 | $28.08 | Total: $1,404.00 |
| 1 | 100 | $24.30 | Total: $2,430.00 |
Data sheet
| Molecular Formula | C27H35N5O2 |
| Molecular Weight | 461.6 |
| CAS Numbers | 1142363-52-7 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1ncc([nH]1)C#N)C1CC(C)(C)OC(C)(C)C1 |
| References | Mancuso R, et al. CSF1R |
More info
Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment.