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CGRP Receptor
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View larger Olcegepant
AT12293L
CAS 204697-65-4
1000 Items
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.10 | Total: $110.50 |
| 1 | 10 | $18.72 | Total: $187.20 |
| 1 | 25 | $15.86 | Total: $396.50 |
| 1 | 50 | $13.52 | Total: $676.00 |
| 1 | 100 | $11.70 | Total: $1,170.00 |
Data sheet
| Molecular Formula | C38H47Br2N9O5 |
| Molecular Weight | 869.65 |
| CAS Numbers | 204697-65-4 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1N(CC=2C(N1)=CC=CC2)C3CCN(C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@H](C(=O)N5CCN(CC5)C=6C=CN=CC6)CCCCN)=O)=O)CC3 |
| References | Rudolf K, et al. Development of human calcitonin gene-related peptide [CGRP] receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-dibromo-N-[[4-[3,4-dihydro-2[1H]-oxoquinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-l-lysyl]-4-[4-pyridinyl]piperazine the first CGRP antagonist for clinical trials in acute migraine. J Med Chem. |
More info
Olcegepant (BIBN-4096) is an effective and selective non-peptide calcitonin gene-related peptide 1 (CGRP1) receptor antagonist (IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP).