Chemokines

CCR2 antagonist 5 View larger

CCR2 antagonist 5

AT27682

CAS 1228650-83-6

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$94.00

$94.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $42.30 Total: $4,230.00
150 $48.88 Total: $2,444.00
125 $57.34 Total: $1,433.50
110 $67.68 Total: $676.80
15 $79.90 Total: $399.50

Data sheet

Molecular FormulaC22H25F3N4O3S
Molecular Weight482.52
CAS Numbers1228650-83-6
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeN(C(CNC(=O)C1=CC(C(F)(F)F)=CC=C1)=O)C2CN([C@@H]3CC[C@@](O)(CC3)C4=CN=CS4)C2
ReferencesDi Prospero NA, Artis E, Andrade-Gordon P, Johnson DL, Vaccaro N, Xi L, Rothenberg P. CCR2 antagonism in patients with type 2 diabetes mellitus a randomized, placebo-controlled study. Diabetes Obes Metab. 2014 Nov;16[11] 1055-64. doi 10.1111dom.12309. Epub 2014 May 25. PubMed PMID 24798870.

More info

CCR2 antagonist 5 (JNJ-41443532) is a selective and orally active hCCR2 inhibitor with good binding affinity (IC50=37 nM) and potent functional antagonism (chemotaxis IC50=30 nM).JNJ-41443532 binds mCCR2 with a Ki of 9.6