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> Chemokines>TC14012 acetate

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TC14012 acetate View larger

TC14012 acetate

ATP2112L

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$65.00

$65.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $55.25 Total: $276.25
110 $46.80 Total: $468.00
125 $39.65 Total: $991.25
150 $33.80 Total: $1,690.00
1100 $29.25 Total: $2,925.00

Data sheet

Molecular FormulaC92H144N34O21S2
Molecular Weight2126.47
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES Code[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)NC([C@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC1=O)CC3=CC=C(C=C3)O)=O)CCCNC(N)=O)=O)CCCCN)=O)CCCNC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CCCNC(N)=N)=O)CCCNC(N)=O)=O)=O)CC5=CC6=CC=CC=C6C=C5)=O)CCCNC(N)=N)=O)CCCNC(N)=N.CC(O)=O
ReferencesH Tamamura, et al. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett. 2001 Jul 23;11[14] 1897-902.

More info

TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is also a potent CXCR7 agonist with an EC50 of 350 nM for recruiting ?-arrestin 2 to CXCR7. TC14012 has anti-cancer activity and anti-HIV activity.