Chlorine Channels

Talniflumate View larger

Talniflumate

AT4503

CAS 66898-62-2

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$26.00

$26.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.70 Total: $1,170.00
150 $13.52 Total: $676.00
125 $15.86 Total: $396.50
110 $18.72 Total: $187.20
15 $22.10 Total: $110.50

Data sheet

Molecular FormulaC21H13F3N2O4
Molecular Weight414.33
CAS Numbers66898-62-2
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeO(C(=O)C1=C(NC2=CC(C(F)(F)F)=CC=C2)N=CC=C1)C3C=4C(C(=O)O3)=CC=CC4
ReferencesKnight D. Talniflumate [Genaera][J]. Current Opinion in Investigational Drugs, 2004, 5[5] 557-62.

More info

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.