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View larger PMX 53 acetate(219639-75-5 free base)
ATP2334
CAS 852629-88-0
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $136.85 | Total: $684.25 |
| 1 | 10 | $115.92 | Total: $1,159.20 |
| 1 | 25 | $98.21 | Total: $2,455.25 |
| 1 | 50 | $83.72 | Total: $4,186.00 |
| 1 | 100 | $72.45 | Total: $7,245.00 |
Data sheet
| Molecular Formula | C49H69N11O9 |
| Molecular Weight | 956.16 |
| CAS Numbers | 852629-88-0 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N=C(N)NCCC[C@@H]1NC([C@H](CC2=CNC3=C2C=CC=C3)NC([C@@H](CC4CCCCC4)NC([C@H]5N(C([C@H](CCCNC1=O)NC([C@H](CC6=CC=CC=C6)NC(C)=O)=O)=O)CCC5)=O)=O)=O.CC(O)=O |
| References | Subramanian H, et al. PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 [MrgX2] in human mast cells. Mol Pharmacol. 2011 Jun;79[6] 1005-13. |
More info
PMX-53 is a potent and orally active CD88 (C5aR) antagonist (IC50: 20 nM) and inhibits C5a-induced neutrophil myeloperoxidase release and chemotaxis with IC50 values of 22 nM and 75 nM, respectively. PMX-53 is also an agonist of Mas-related gene 2 (MrgX2).