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L-744832
AOB8767
CAS 1177806-11-9
Chemical Name: Propan-2-yl (2S)-2-[[(2S)-2-[(2S,3R)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoate dihydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $57.15 | Total: $5,715.00 |
| 1 | 50 | $66.04 | Total: $3,302.00 |
| 1 | 25 | $77.47 | Total: $1,936.75 |
| 1 | 10 | $91.44 | Total: $914.40 |
| 1 | 5 | $107.95 | Total: $539.75 |
Data sheet
| Molecular Formula | C26H47Cl2N3O6S2 |
| Molecular Weight | 632.70 |
| CAS Numbers | 1177806-11-9 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | PD160021 |
| IUPAC/Chemical Name | Propan-2-yl (2S)-2-[[(2S)-2-[(2S,3R)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoate dihydrochloride |
| InChl Key | PGOKBMWPBDRDGN-ZXGKGEBGSA-N |
| InChl Code | InChI=1S/C26H45N3O6S2/c1-6-19(4)23(28-15-21(27)17-36)16-34-24(14-20-10-8-7-9-11-20)25(30)29-22(12-13-37(5,32)33)26(31)35-18(2)3/h7-11,18-19,21-24,28,36H,6,12-17,27H2,1-5H3,(H,29,30)/t19-,21-,22+,23-,24+/m1/s1 |
| SMILES Code | CCC(C)C(COC(CC1=CC=CC=C1)C(=O)NC(CCS(=O)(=O)C)C(=O)OC(C)C)NCC(CS)N |
| References | 1) Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK: Y. Dai, et al.; Blood 105, 1706 (2005) |
More info
Ras farnesyltransferase inhibitor, inhibiting in p70(s6k) phosphorylation in mammary tumors, inducing tumor regression in transgenic mice by mediating alterations in both cell cycle control and apoptosis