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Wnk-in-b

AOB8293

CAS 332922-63-1

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Novel inhibitor of lysine deficient protein kinase (WNK) signaling, disrupting the binding of WNK to SPAK. inhibiting hypotonicity-induced activation of WNK and its downstream transporters NKCC1 (Na/K/Cl cotransporter 1) and NCC (NaCl cotransporter)