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Natural inhibitor of the KEAP1-NRF2 interaction, inhibiting orexigenic neuropeptides NPY and AgRP, activating NRF2 and ameliorating dextran sulfate sodium-induced colitis, also showing a variety of intriguing biological properties such as anti-thrombotic, anticancer, anti-inflammatory and analgesic, anti-obesity and thermoregulatory, vasorelaxing activity, as well as effects on the cardiovascular and endocrine systems