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natural potent inhibitor of rat lens AR (rAR) and human recombinant AR (rhAR), also inhibiting sorbitol formation of rat lens incubated with a high concentration of glucose, regulating BACE1 transcription factors by inducing the expression of peroxisome proliferator activated receptor γ (PPARγ) and inhibiting the phosphorylation of signal transducer and activator of transcription 3