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Uc-514321 View larger

Uc-514321

AOB13689

CAS 299420-83-0

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Novel selective TET1-signaling inhibitor, directly bind to the DBD of STAT3/5, showing an enhanced effect in repressing the viability of TET1-high AML (including MONOMAC-6, THP-1, and KASUMI-1) cells, as compared with NSC-370284 and other JAK/STAT inhibitors, e.g. Pacritinib, KW-2449, STAT3/5 inhibitor Stattic, or STAT5 inhibitor SC-355979